President Donald Trump鈥檚 largely sidestepped questions Thursday from senators about how he would handle numerous pressing issues before the agency, including , a canceled vaccine meeting and the continued availability of the
鈥� a surgeon, author and researcher 鈥� lauded the FDA鈥檚 鈥済old-standard science鈥� in testimony before the Senate鈥檚 health committee, which must vote on whether to advance his nomination. A professor at Johns Hopkins University, Makary is known for his contrarian views and previously called the FDA 鈥渂roken,鈥� and 鈥渕ired in politics and red tape鈥� while working as a commentator for Fox News.
He repeatedly assured Republican and Democratic senators he would follow the 鈥渟cientific process鈥� at FDA. But he wouldn't commit to specific actions on a host of hot-button issues, including the abortion pill , which has been ensnared in politics since a 2021 decision by FDA making it available by mail.
鈥淚 have no preconceived plans on mifepristone policy except to take a hard look at the data and to meet with the professional career scientists at the FDA who have reviewed the data,鈥� Makary told Sen. Bill Cassidy, the Louisiana Republican who chairs the health committee.
Makary's remarks echoed those of , who told lawmakers in January he wants to 鈥渟tudy鈥� the safety of mifepristone and a host of other long-established therapies, including antidepressants, childhood vaccines and attention-deficit drugs. The prospect of Trump officials overturning the approval of FDA-approved medicines is a growing concern for physicians, medical researchers and drugmakers.
Mifepristone was approved roughly 25 years ago and FDA scientists have repeatedly reaffirmed its safety over the years, easing limits on its use, including eliminating a requirement that patients pick it up in person.
Like other drugs, the FDA continues to collect reports of side effects and complications with mifepristone. Makary said he wouldn鈥檛 鈥減rejudge the data without seeing it.鈥�
That idea didn鈥檛 reassure Sen. Maggie Hassan, one of several Democrats who pressed Makary to commit to keeping the drug available under its current framework, which allows online prescribing by health professionals.
鈥淭he concern is whether you are going to unilaterally overrule the data that currently exists for political purposes," the New Hampshire senator said, referring to dozens of studies supporting the drug's safe use. 鈥淲e need to know when you say that you鈥檙e an independent scientist, that鈥檚 what you really mean.鈥�
FDA commissioners aren鈥檛 typically involved in the agency鈥檚 day-to-day medical reviews, but they often serve as a buffer between FDA scientists and political forces elsewhere in government.
If confirmed, Makary would take over at a particularly turbulent period for the agency. Last month, the FDA abruptly fired hundreds of staffers across multiple parts of the agency, only to rehire some of them a week later. The agency鈥檚 top food regulator and several other senior leaders have resigned or retired in recent weeks.
Makary told lawmakers he was "not involved鈥� in any of the recent staff reductions and would do his own assessment on whether some employees should be rehired.
Similarly, Makary said he had no involvement in FDA鈥檚 recent decision to abruptly cancel a meeting of outside vaccine experts who were scheduled to make recommendations for next season鈥檚 flu shots. He downplayed the significance of the meeting and wouldn't commit to rescheduling it, noting that in previous years the FDA panel 鈥渞ubber-stamped鈥� recommendations made by international vaccine authorities.
As commissioner, Makary said he would 鈥渞eevaluate鈥� which vaccine topics merit consulting the agency's outside advisors.
Trump administration officials said FDA鈥檚 staff scientists will choose strains for the shots and send them to manufacturers, ensuring that updated vaccines are ready for the fall.
鈥淲hat is lost is the transparency,鈥� said Cassidy, who said eliminating the public discussion on vaccines cuts against Kennedy鈥檚 pledge for 鈥渞adical transparency," in health decisions.
The cancellation marked the second time in less than a week that the Trump administration intervened in a previously scheduled vaccine meeting. A late February meeting of the Centers for Disease Control and Prevention's vaccine advisory panel has been postponed, with no new date set.
Kennedy recently called for a to review the safety of a number of FDA-approved products, including vaccines, weight-loss drugs and stimulants. Given Kennedy鈥檚 , health groups and Democratic lawmakers have warned that he could appoint new experts who share his beliefs to FDA's vaccine advisory panel.
Again, Makary said he has 鈥渘o preconceived plans to rearrange that committee or any committee,鈥� and he defended Kennedy鈥檚 efforts: 鈥淪ecretary Kennedy wants to make America healthy again.鈥�
Compared with Kennedy, Makary is considered one of Trump鈥檚 more conventional health nominees and is widely expected to be confirmed. A full Senate vote on his nomination is expected in the coming weeks.
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The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute鈥檚 Science and Educational Media Group and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.
Matthew Perrone, The Associated Press
