The company at the
Emergent BioSolutions, a little-known company vital to the vaccine supply chain, was a key to Johnson & Johnson's plan to deliver 100 million doses of its single-shot vaccine to the United States by the end of May. But the Food and Drug Administration repeatedly has cited Emergent for problems such as poorly trained employees, cracked vials and problems managing
Johnson & Johnson said Wednesday that a batch of vaccine made by Emergent at its Baltimore factory, known as Bayview, cannot be used because it did not meet quality standards. It was unclear how the problem would affect future deliveries of J&J's vaccine. The company said in a statement it was still planning to deliver 100 million doses by the end of June and was 鈥渁iming to deliver those doses by the end of May.鈥�
鈥淗uman errors do happen," Dr. Anthony Fauci, the nation鈥檚 top infectious disease expert, said Thursday in an interview on CBS' 鈥淭his Morning.鈥� "You have checks and balances. ... That鈥檚 the reason why the good news is that it did get picked up. As I mentioned, that鈥檚 the reason nothing from that plant has gone into anyone that we鈥檝e administered to.鈥�
White House press secretary Jen Psaki said Thursday that none of the J&J vaccine doses on the market are affected and the company was on track to deliver 24 million doses in April and 100 million doses by the end of May.
鈥淭hese are doses that the U.S. government has purchased, but we also have plenty of doses from Pfizer and Moderna, regardless, Psaki said.鈥�
J&J locked arms with Emergent in April 2020, enlisting the lesser-known company to manufacture the vaccine J&J was developing with federal money. At the time, Emergent鈥檚 Bayview facility wasn鈥檛 scaled for making millions of doses of a potential COVID-19 vaccine, according to the FDA records, which describe the plant as a contract testing laboratory that 鈥渄id not manufacture products for distribution.鈥� Upgrades in technology and personnel were required before Bayview could begin making what is known as 鈥渄rug substance鈥� material for the vaccine, a two-month process during which the required biological cells are grown.
The FDA inspected Emergent鈥檚 Bayview plant in April 2020, just as the agreement with J&J was being announced. The federal agency criticized Emergent for problems with its testing of a potential treatment for anthrax, according to the records obtained by the AP. The FDA鈥檚 lead investigator cited the company for failing to train employees 鈥渋n the particular operations they perform as part of their function and current good manufacturing practices.鈥�
On the same day, Johnson & Johnson, in a separate news release, heralded its partnership with Emergent as a step toward the pharmaceutical giant鈥檚 goal of supplying more than 1 billion doses of the vaccine globally by the end of 2021.
But the FDA鈥檚 inspection of Emergent鈥檚 Bayview plant had faulted the company for a series of quality control shortcomings, according to the records. Although the inspection was not triggered by work on a COVID-19 vaccine, the issues listed by agency inspectors stand out due to the large role Emergent would soon have to combat the pandemic.
The FDA criticized the Bayview plant for failing to ensure that electronic data generated through testing of drug ingredients 鈥渨as protected from deletion or manipulation.鈥� A closer review found 202 deletions and 543 reprocessed files, yet the company had not investigated how those alterations had occurred or their possible impact, according to the records. The FDA鈥檚 lead investigator, Marcellinus Dordunoo, wrote that Emergent had not investigated what he described as 鈥渄ata integrity concerns.鈥�
Emergent also did not follow proper testing and lab procedures at Bayview, the FDA said, noting that 鈥渄eviations from test methods are not investigated, and are manually corrected days after performance, with no supporting data or documented justification.鈥�
The FDA also criticized Emergent for carelessness in the handling of rejected materials in the Bayview plant. An inspector observed items in a 鈥渞eject cage鈥� that did not have reject labels, and wrote that 鈥渟eparate or defined areas to prevent contamination or mix-ups are deficient.鈥�
The inspection was the most recent in a series of critical reports from the FDA about Emergent, including one following a December 2017 inspection at a plant in Canton, Massachusetts, in which the FDA said the company had not corrected 鈥渃ontinued low level
In September 2018, agency investigators questioned why Emergent had 鈥渁n unwritten policy of not conducting routine compliance audits鈥� at a separate plant in Baltimore, known as Camden, where an anthrax vaccine, BioThrax, is filled into vials.
A few months earlier, FDA inspectors noted that the company's processes there were flawed. 鈥淵our firm received 3 complaints for residue on the outside of the vials for 3 different lots,鈥� the FDA's inspection report said. Tests on that residue confirmed it was vaccine, according to the June 2018 report.
The agency, in another finding from that inspection, noted Emergent's ongoing problems managing contamination at the Camden facility: 鈥淧rocedures designed to prevent microbiological contamination of drug products purporting to be sterile are not adequately established and followed.鈥� FDA's inspectors also noted that Emergent staff filling vials of vaccine held 鈥渢heir hands directly above open vials鈥� in a way that violated sterility safeguards.
The FDA declined repeated requests to discuss the inspections at Emergent鈥檚 facilities. A spokesman said the agency 鈥渃annot comment on any particular company or any potential or ongoing compliance matters.鈥�
In an emailed statement, Emergent spokesman Matt Hartwig said the company鈥檚 鈥渞igorous quality checks鈥� identified a batch of drug substance that did not meet its standards.
鈥淒iscarding a batch of bulk drug substance, while disappointing, does occasionally happen during vaccine manufacturing, which is a complex and multi-step biological process,鈥� he said.
Emergent鈥檚 revenues skyrocketed during the Trump administration, from about $523 million in 2015 to more than $1.5 billion in 2020. Emergent has invested heavily in lobbying the federal government, according to disclosure records that show the company spent $3.6 million on lobbying in 2020 alone.
Emergent is one of about eight companies that Johnson & Johnson is using to speed up manufacturing of its recently approved coronavirus vaccine, the company said. The Bayview factory where the tainted vaccine ingredient was found had not yet been approved by the FDA, so no vaccine in circulation is affected.
President Joe Biden has pledged to have enough vaccines for all U.S. adults by the end of May. The U.S. government has ordered enough two-dose shots from Pfizer and Moderna to vaccinate 200 million people to be delivered by late May, plus the 100 million single-dose shots from J&J.
A federal official said Wednesday evening that the administration鈥檚 goal can be met without additional J&J doses.
A J&J spokesman said earlier Wednesday that the company met the end-of-March goal. The Centers for Disease Control and Prevention鈥檚 online vaccine tracker showed J&J had provided about 6.8 million doses to the U.S. vaccine effort. J&J has been shipping finished vaccines from its factory in the Netherlands to the U.S.
J&J said it was putting more of its manufacturing and quality experts inside Emergent鈥檚 factory to supervise production of the COVID-19 vaccine, a move meant to enable delivery of an additional 24 million vaccine doses through April.
J&J said it still expects to deliver more than 1 billion vaccine doses globally by the end of the year.
The J&J vaccine has been viewed as crucial for vaccination campaigns around the world because only one shot is required and it can be shipped and stored at standard refrigeration temperatures, unlike some other vials that must be kept frozen. The company also has pledged to sell the vaccine without a profit, but only during the pandemic emergency.
The problem with the vaccine batch was first reported by The New York Times. The FDA said it was aware of the situation but declined further comment.
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Lardner reported from Washington, Dearen from Gainesville, Florida, and Johnson from Fairless Hills, Pennsylvania. Associated Press writers Matthew Perrone and Zeke Miller in Washington contributed to this report.
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Contact AP鈥檚 global investigative team at [email protected]. Follow Richard Lardner on Twitter at @RPLardner. Follow Jason Dearan on Twitter at @JHDearen and Linda Johnson at @LindaJ_onPharma
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This story has been corrected to show the name of the company is Emergent BioSolutions, not Emergent BioSolutons.
Richard Lardner, Jason Dearen And Linda A. Johnson, The Associated Press
